Patrick McNamara, PhD

Professor Emeritus

Patrick J. McNamara received his Ph.D. in Pharmaceutical Sciences from the State University of New York at Buffalo in 1979. He joined the faculty at the University of Kentucky in 1980 and has advanced through the academic ranks. Prior to his appointment as Senior Associate Dean for the College of Pharmacy, he served as Director (Division of Pharmaceutics and Pharmaceutical Analysis; Pharmacology and Experimental Therapeutics; and Pharmaceutical Sciences), Chair of the Department of Pharmaceutical Sciences, Associate Dean for Research and Director of Graduate Studies as well as Interim Dean of the College of Pharmacy.

Dr. McNamara has a joint appointment in the Graduate Center for Toxicology and is a member of the Markey Cancer Center. He is a Fellow in American Association of Pharmaceutical Sciences and the American Association for the Advancement of Science. He serves on the Editorial Advisory Board for the Journal of Pharmaceutical Sciences and serves as a reviewer for numerous journals. Dr. McNamara has served as a consultant to a number of pharmaceutical companies.

Dr. McNamara's scholarly interests are in the areas of pharmacokinetics and pharmacodynamics, with a particular emphasis on drug transport into milk and the ontogeny of clearance pathways. Dr. McNamara's most recent work has focused on the mechanisms of drug transfer into milk, including transporter gene expression at the blood mammary epithelial barrier. Ongoing research also examines influence of transporters expressed at the blood brain barrier on the penetration of drugs into the CNS. Other projects include modeling the pharmacodynamic of bacterial resistance mechanisms (i.e., up-regulation of efflux transporters and mutations of QRDRs) upon exposure to fluroquinolones. Dr. McNamara's research program utilizes contemporary technology, including cell culture, molecular biology, whole-animal and clinical studies, microdialysis, high-performance liquid chromatography, computer model fitting and simulations.

PUBLICATIONS