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A Commitment to Positive Impact Throughout the Commonwealth

The Center for Pharmaceutical Research and Innovation (CPRI) facilitates basic and clinical research in drug discovery and development. The CPRI assists UK-based researchers to identify novel chemical probes and drug leads to address unmet medical needs in various disease areas and assisting in advancing projects to in vivo preclinical proof of principle. Through our Computational, Synthesis, and Translational Cores, and our Natural Products Library we provide unique services and build innovative research collaborations with investigators across the university.


Our scientists are the intellectual engine of CPRI and innovators in team-driven probe/lead discovery, development, and commercialization.

Research Core and Resources

The CPRI provides core services, state-of-the-art facilities, and unique expertise to facilitate translational research.

CPRI Collaborative Projects

CPRI works with many talented UK investigators and the network of world-class UK Centers focused on major health disparities in the Commonwealth.

CPRI and COBRE Publications

Representative publications from CPRI and COBRE researchers and Google Scholar Dashboard


CoP faculty in biomedical startup competition

CPRI collaborator, Dr. Linda Dwoskin, finished 2nd in regional competition for biomedical startups.

Prisinzano Named New Director

The CPRI welcomes Dr. Tom Prisinzano as the new director.

Seeking Cures in Kentucky Coal Mines

Read more about how natural products-based lead to discovery in our Newsweek feature.


NIH Awards $11.2 Million for Pharmaceutical Research and Innovation Center at UK

The University of Kentucky was awarded a prestigious Centers of Biomedical Research Excellence (COBRE) grant to study translational chemical biology from the National Institutes of General Medical Sciences, part of the National Institutes of Health.


The CPRI seeks to develop innovative research partnerships with UK investigators. For more information and to request services, please contact us.

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Funding Acknowledgment Statement

This work was supported by the Center for Pharmaceutical Research and Innovation (CPRI, NIH P20 GM130456) and the National Center for Advancing Translational Sciences (UL1 TR001998).

We wish to remember and honor those who inhabited this Commonwealth before the arrival of the Europeans. Briefly occupying these lands were the Osage, Wyndott tribe, and Miami peoples. The Adena and Hopewell peoples, who are recognized by the naming of the time period in which they resided here, were here more permanently. Some of their mounds remain in the Lexington area, including at UK’s Adena Park.

In more recent years, the Cherokee occupied southeast Kentucky, the Yuchi southwest Kentucky, the Chickasaw extreme western Kentucky and the Shawnee central Kentucky including what is now the city of Lexington. The Shawnee left when colonization pushed through the Appalachian Mountains. Lower Shawnee Town ceremonial grounds are still visible in Greenup County.

We honor the first inhabitants who were here, respect their culture, and acknowledge the presence of their descendants who are here today in all walks of life including fellow pharmacists and healthcare professionals.