UK’s fertile scientific environment, outstanding faculty, and collaborative spirit are key drivers of CPRI’s success. The individual core leaders work directly and collaboratively with UK investigators on study design, implementation, and prioritization to accomplish specific project outcomes. Ongoing projects are reviewed/prioritized on a monthly basis by the CPRI core leadership team to facilitate advancement.
Since its inception in 2012, CPRI has engaged in 83 distinct collaborative projects representing 7 UK Colleges, 6 external academic institutions (including two in Kentucky – EKU and NKU), 5 companies, 2 non-profits, and 1 government agency. During this same time frame, CPRI has contributed to 126 peer-reviewed publications, 14 issued patents, and new extramural grants to UK totaling $49.4M in direct costs ($68.3M total costs). CPRI key resource utilization across all projects to date is well-distributed (Computational Core, 19%; Synthesis Core, 30%; Translational Core 29%; Natural Products Repository, 21%) where most projects make use of more than one key resource.
S-adenosylmethionine synthase (MAT2A) antagonists (PI: Dr. Chunming Liu)
Ye Q, Zhang Y, Cao Y, Wang X, Guo Y, Chen J, Horn J, Ponomareva LV, Chaiswing L, Shaaban KA, Wei Q, Anderson BD, St Clair DK, Zhu H, Leggas M, Thorson JS, She QB (2019). Frenolicin B targets peroxiredoxin 1 and glutaredoxin 3 to trigger ROS/4E-BP1-mediated antitumor effects. Cell Chemical Biology 26(3):366-377. PMCID: PMC6557261
Elshahawi SI, Cao H, Shaaban KA, Ponomareva LV, Subramanian T, Farman ML, Spielmann HP, Phillips GN Jr, Thorson JS, Singh S (2017). Structure and specificity of a permissive bacterial C-prenyltransferase. Nature Chemical Biology 13(4):366-368. PMCID: PMC5362326
Sviripa VM, Burikhanov R, Obiero JM, Yuan Y, Nickell JR, Dwoskin LP, Zhan CG, Liu C, Tsodikov OV, Rangnekar VM, Watt DS (2016). Par-4 secretion: Stoichiometry of 3-arylquinoline binding to vimentin. Organic & Biomolecular Chemistry 14(1):74-84. PMCID: PMC4681656
Zhang Y, Ye Q, Wang X, She QB, Thorson JS (2015). A divergent enantioselective strategy for the synthesis of griseusins. Angewandte Chemie International Edition 54(38):11219-11222. PMCID: PMC4565752
Burikhanov R, Sviripa VM, Hebbar N, Zhang W, Layton WJ, Hamza A, Zhan CG, Watt DS, Liu C Rangnekar VM (2014). Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis. Nature Chemical Biology 10(11):924-926. PMCID: PMC4201913
Zhang W, Sviripa V, Chen X, Shi J, Yu T, Hamza A, Ward NS, Kril LM, Vander Kooi CW, Zhan CG, Evers BM, Watt DS, Liu C (2013). Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chemical Biology 8(4):796-803. PMCID: PMC3631441
The CPRI seeks to develop innovative research partnerships with UK investigators. For more information and to request services, please contact us.
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This work was supported by the University of Kentucky COBRE for Translational Chemical Biology (CTCB, NIH P20 GM130456) and the University of Kentucky Center for Clinical and Translational Science (CCTS, NIH UL1 TR001998).
