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UK’s fertile scientific environment, outstanding faculty, and collaborative spirit are key drivers of CPRI’s success. The individual core leaders work directly and collaboratively with UK investigators on study design, implementation, and prioritization to accomplish specific project outcomes. Ongoing projects are reviewed/prioritized on a monthly basis by the CPRI core leadership team to facilitate advancement.

Since its inception in 2012, CPRI has engaged in 83 distinct collaborative projects representing 7 UK Colleges, 6 external academic institutions (including two in Kentucky – EKU and NKU), 5 companies, 2 non-profits, and 1 government agency. During this same time frame, CPRI has contributed to 126 peer-reviewed publications, 14 issued patents, and new extramural grants to UK totaling $49.4M in direct costs ($68.3M total costs). CPRI key resource utilization across all projects to date is well-distributed (Computational Core, 19%; Synthesis Core, 30%; Translational Core 29%; Natural Products Repository, 21%) where most projects make use of more than one key resource.

Representative Projects

Cancer

Infectious Disease

  • Chemical probes for bacterial type IV secretion systems (PI: Dr. Carrie Shaffer)
  • Agents for systemic fungal diseases (PI: Dr. Sylvie Garneau-Tsodikova)
  • Strategies for biofilm characterization and disruption (PI: Dr. Meg Grady)
  • Computational approaches to antibiotic discovery (PI: Dr. Yinan Wei)

Substance Use Disorder

Technology/Resource Development

Representative Publications

Inquiries

The CPRI seeks to develop innovative research partnerships with UK investigators. For more information and to request services, please contact us.

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Funding Acknowledgment Statement

This work was supported by the Center for Pharmaceutical Research and Innovation (CPRI, NIH P20 GM130456) and the National Center for Advancing Translational Sciences (UL1 TR001998).