By combining structural biology, biophysical chemistry and computation, Dr. Tsodikov’s group is working on understanding biological mechanisms involved in bacterial infection and cancer. The specific areas of interest are DNA replication, bacterial persistence and drug resistance in Mycobacterium tuberculosis and other bacterial pathogens, and mechanisms of oncogenic transcription factors. The basic scientific inquiry is fueling a target-based drug discovery effort in finding, characterizing and developing novel inhibitors of these processes. Oleg Tsodikov graduated summa cum laude from Moscow Institute of Physics and Technology with a M. S. in 1994 and joined the Ph.D. program in biophysics at the University of Wisconsin-Madison. His work in Professor Tom Record’s laboratory was focused on using biophysical chemistry and computational methods to study fundamental protein-DNA interactions involved in prokaryotic transcription initiation. From Wisconsin, Dr. Tsodikov moved to Harvard Medical School, where he was a postdoctoral fellow in Professor Tom Ellenberger’s group. At Harvard, he carried out structural and biochemical studies of human nucleotide excision repair proteins. Before joining the University of Kentucky, Dr. Tsodikov was an Assistant Professor at the Department of Medicinal Chemistry at the University of Michigan.