Dr. Jurgen Rohr
Dr. Rohr's research is focused on natural product drugs, i.e. antibiotics, anticancer drugs and drugs against bone diseases. It includes the elucidation of complex multi-step biosynthetic pathways, carried out by bacteria, fungi or plants, with particular emphasis on enzyme mechanisms. The results of these biosynthetic studies are used to generate modified natural product drugs through genetic engineering (pathway engineering, combinatorial biosynthesis). Used techniques in the Rohr-laboratory include isolation and structure elucidation of natural products, incorporation experiments with isotope-labeled biosynthetic precursors, NMR spectroscopy, mass spectrometry, and recombinant DNA techniques for the targeted interruption or recombination of genes of the biosynthetic pathways. Newer aspects of the research include (i) generation and testing of new antitumor drugs and drugs against bone diseases, (ii) the investigation of biochemical mechanisms of anticancer drugs, and (iii) discovery and investigation of new antibacterials. Dr. Rohr's publications (ca. 190) can be found in biochemical and chemical journals, such as Angew. Chem., Biochemistry, Chem. Biol., ChemBioChem, Chem. Commun., Gene, J. Am. Chem. Soc., J. Bacteriol., J. Biol. Chem., J. Nat. Prod., J. Org. Chem., Microbiol., Mol. Gen. Genet., Nat. Prod. Rep. etc. Before joining University of Kentucky, Dr. Rohr was Assistant and Associate Professor at the Department of Chemistry and Biochemistry of the University of Göttingen, Germany and Associate Professor at the Department of Pharmaceutical Sciences of the Medical University of South Carolina, Charleston, SC.