Dr. Jurgen Rohr
Dr. Jurgen Rohr

Professor

Dr. Rohr's research is focused on natural product drugs, i.e. antibiotics, anticancer drugs and drugs against bone diseases. It includes the elucidation of complex multi-step biosynthetic pathways, carried out by bacteria, fungi or plants, with particular emphasis on enzyme mechanisms. The results of these biosynthetic studies are used to generate modified natural product drugs through genetic engineering (pathway engineering, combinatorial biosynthesis). Used techniques in the Rohr-laboratory include isolation and structure elucidation of natural products, incorporation experiments with isotope-labeled biosynthetic precursors, NMR spectroscopy, mass spectrometry, and recombinant DNA techniques for the targeted interruption or recombination of genes of the biosynthetic pathways. Newer aspects of the research include (i) generation and testing of new antitumor drugs and drugs against bone diseases, (ii) the investigation of biochemical mechanisms of anticancer drugs, and (iii) discovery and investigation of new antibacterials. Dr. Rohr's publications (ca. 190) can be found in biochemical and chemical journals, such as Angew. Chem., Biochemistry, Chem. Biol., ChemBioChem, Chem. Commun., Gene, J. Am. Chem. Soc., J. Bacteriol., J. Biol. Chem., J. Nat. Prod., J. Org. Chem., Microbiol., Mol. Gen. Genet., Nat. Prod. Rep. etc. Before joining University of Kentucky, Dr. Rohr was Assistant and Associate Professor at the Department of Chemistry and Biochemistry of the University of Göttingen, Germany and Associate Professor at the Department of Pharmaceutical Sciences of the Medical University of South Carolina, Charleston, SC.

Recent Publications

  • Rohr Jurgen, Pahari Pallab. (2016). Synthesis of Psoralidin derivatives and their anticancer activity: first synthesis of Lespeflorin I 1. Tetrahedron, 72(23), 3324-3334.
  • Rohr Jurgen, Tsai Sheryl. (2016). Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE. ACS Chemical Biology, 11(4), 1137-1147.
  • Lehka L V, Panchuk R R, Berger W, Rohr Jurgen, Stoika R S. (2015). THE ROLE OF REACTIVE OXYGEN SPECIES IN TUMOR CELLS APOPTOSIS INDUCED BY LANDOMYCIN A. Ukrainian biochemical journal, 87(5), 72-82.
  • Rohr Jurgen, Eckenrode Joseph, Horn Jamie, Chen Jhong-min , Leggas Markos . (2015). Mithramycin analogs with reduced toxicity for EWS-FLI1 targeting. Cancer Research, 75, 2628-2628.
  • Lassak J, Keilhauer E C, Fürst M, Wuichet K, Gödeke J, Starosta A L, Chen J M, Søgaard-Andersen L, Rohr Jurgen, Rohr Jurgen, Häussler S, Mann M, Jung K. (2015). Corrigendum: Arginine-rhamnosylation as new strategy to activate translation elongation factor P. Nature chemical biology, 11(4), 299.
  • Lassak J, Keilhauer E C, Fürst M, Wuichet K, Gödeke J, Starosta A L, Chen J M, Søgaard-Andersen L, Rohr Jurgen, Rohr Jurgen, Häussler S, Mann M, Jung K. (2015). Arginine-rhamnosylation as new strategy to activate translation elongation factor P. Nature chemical biology, 11(4), 266-70.
  • Tam H K, Härle J, Gerhardt S, Rohr Jurgen, Wang Gui-mei, Thorson Jon S, Bigot A, Lutterbeck M, Seiche W, Breit B, Bechthold A, Einsle O. (2015). Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2. Angewandte Chemie (International ed. in English), 54(9), 2811-5.
  • Tam Heng K, Haerle Johannes , Gerhardt S, Wang G, Rohr J, Thorson J S, Bigot A, Lutterbeck M, Seiche W, Breit B, Bechthold A, Einsle O. (2015). Structural Characterization of O- and C-Glycosylating Variants of the Landomycin Glycosyltransferase LanGT2. Angew Chem Int Ed, 54(9),
  • Rohr Jurgen. (2015). N-methylphenylalanyl-dehydrobutyrine diketopiperazine, an A-factor mimic that restores antibiotic biosynthesis and morphogenesis in Streptomyces globisporus 1912-B2 and Streptomyces griseus 1439. Journal of Antibiotics, 68(1), 9-14.
  • Chen J M, Shepherd M D, Horn J, Leggas Markos, Rohr Jurgen. (2014). Enzymatic methylation and structure-activity-relationship studies on polycarcin v, a gilvocarcin-type antitumor agent. Chembiochem : a European journal of chemical biology, 15(18), 2729-35.