The Chem Core engages in the synthesis of non-commercial agents, hit/lead discovery/development chemistries, medicinal chemistry and/or the modification (e.g., using suitable reactive tags, isotopes, fluorophores) of bioactive probes, drugs or natural products for target identification studies (in conjunction with the UK Mass Spectrometry and Proteomics Core). Small molecule-based probe and hit/lead discovery synthetic projects in the core also commonly leverage computational models, computational de novo design, and/or computational ADMET. The CTCB Chem Core works closely with the CTCB Bio Core for bioactivity-guided probe/lead prioritization. The Chem Core is directed by Professor Tom Prisinzano and co-directed by Professor Chang-Guo Zhan.
The Chem Core welcomes inquiries from UK investigators with an interest in the application of organic synthesis, medicinal chemistry, and/or chemical biology approaches to facilitate on-going or emerging research projects. For more information and to request services, please contact us.
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This work was supported by the University of Kentucky COBRE for Translational Chemical Biology (CTCB, NIH P20 GM130456) and the University of Kentucky Center for Clinical and Translational Science (CCTS, NIH UL1 TR001998).
