The Chem Core engages in the synthesis of non-commercial agents, hit/lead discovery/development chemistries, medicinal chemistry and/or the modification (e.g., using suitable reactive tags, isotopes, fluorophores) of bioactive probes, drugs or natural products for target identification studies (in conjunction with the UK Mass Spectrometry and Proteomics Core). Small molecule-based probe and hit/lead discovery synthetic projects in the core also commonly leverage computational models, computational de novo design, and/or computational ADMET. The CTCB Chem Core works closely with the CTCB Bio Core for bioactivity-guided probe/lead prioritization. The Chem Core is directed by Professor Tom Prisinzano and co-directed by Professor Chang-Guo Zhan.