CTCB Research Cores and Resources

The Computational Core provides consultation, staff, software and expertise to support virtual screening, predictive toxicology, computational modeling of drug-target interactions and ligand design using a variety of state-of-the-art molecular modeling, stimulation and computational techniques.

The Synthesis Core provides consultation, staff, reagents and equipment for the synthesis of small molecules to support the identification, development and application of novel probes and hits/leads.

The Bio Core provides consultation, staff, compound libraries, and expertise to support biochemical, cell-based, and whole animal assay development and screening for probe/hit discovery and optimization.

The Chem Core provides consultation, staff, reagents and equipment for the synthesis of small molecules to support the identification, development and application of novel probes and hits/leads.

CPRI houses a range of commercially-sourced and UK-exclusive compound collections to support collaborative screening projects conducted in the Bio Core or via select external screening center partnerships. 

The Translational Core provides consultation, staff, compound libraries, and expertise to support biochemical, cell-based, and whole animal assay development and screening for probe/hit discovery and optimization. The core also supports preliminary hit/lead in vitro and in vivo evaluation with a particular focus on microsomal metabolism, pharmacokinetics (PK), pharmacodynamics (PD), and basic toxicology (MTD).

CPRI facilitates the development and implementation of unique tools and reagents to support translational research and drug discovery and development. These include commercially-sourced and UK-exclusive compound libraries, alternative animal models, assays, and computational tools.