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Computational Core

The Computational Core provides consultation, staff, software and expertise to support virtual screening, predictive toxicology, computational modeling of drug-target interactions and ligand design using a variety of state-of-the-art molecular modeling, stimulation and computational techniques.

Synthesis Core

The Synthesis Core provides consultation, staff, reagents and equipment for the synthesis of small molecules to support the identification, development and application of novel probes and hits/leads.

Translational Core

The Translational Core provides consultation, staff, compound libraries, and expertise to support biochemical, cell-based, and whole animal assay development and screening for probe/hit discovery and optimization. The core also supports preliminary hit/lead in vitro and in vivo evaluation with a particular focus on microsomal metabolism, pharmacokinetics (PK), pharmacodynamics (PD), and basic toxicology (MTD).

 

Tools and Reagents

CPRI facilitates the development and implementation of unique tools and reagents to support translational research and drug discovery and development. These include commercially-sourced and UK-exclusive compound libraries, alternative animal models, assays, and computational tools.

Inquiries

The CPRI seeks to develop innovative research partnerships with UK investigators. For more information and to request services, please contact us.

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Funding Acknowledgment Statement

This work was supported by the Center for Pharmaceutical Research and Innovation (CPRI, NIH P20 GM130456) and the National Center for Advancing Translational Sciences (UL1 TR001998).