Under the directorship of Professor Khaled Shaaban, CPRI has developed the CPRI Natural Products Repository as UK-exclusive enabling resource. This repository is a growing collection of >420 pure natural products (>50% of which are unique to our collection) produced by microbes isolated from subterranean environments in Appalachian Kentucky (through strategic collaborations with KY-based underground mining and drilling operations).
This effort has expanded to include strategic international collaborations to enable access to new ecological niches and natural products (Dr. Chirlei Glienke, Federal University of Paraná; Dr. Imran Sajid, University of the Punjab, Pakistan; Dr. Changsheng Zhang, South China Sea Institute of Oceanology, China). As part of our natural products emphasis, CPRI also houses >1100 distinct actinomycete strains and corresponding fractionated extracts in screenable format. CPRI has also identified overproduction sources for a number of specialty natural products and continues to build a collection of UK-exclusive synthetics to further facilitate translational research activities.
In addition to the UK-exclusive compound collections emphasized above, CPRI continues to maintain and build a collection of commercially-sourced compound collections to support screening projects (including those focused on drug repurposing/repositioning). All CPRI compound collections listed below are available in a standard screenable format via the Translational Core and, for select projects, compounds can also be provided on larger scale for medicinal chemistry, mechanistic studies, in vivo assessment and/or development activities through the Synthesis Core.
Savi DC, Shaaban KA, Gos FMWR, Ponomareva LV, Thorson JS, Glienke C, Rohr J (2018). Phaeophleospora vochysiae Savi & Glienke sp. nov. isolated from Vochysia divergens found in the Pantanal, Brazil, produces bioactive secondary metabolites. Scientific Reports 8(1):3122. PMCID: PMC5814415
HP, Phillips GN Jr, Thorson JS, Singh S (2017). Structure and specificity of a permissive bacterial C-prenyltransferase. Nature Chemical Biology 13(4):366-368. PMCID: PMC5362326
Cai W, Wang X, Elshahawi SI, Ponomareva LV, Liu X, McErlean MR, Cui Z, Arlinghaus AL, Thorson JS, Van Lanen SG (2016). Antibacterial and cytotoxic actinomycins Y6-Y9 and Zp from Streptomyces sp. strain Gö-GS12. Journal of Natural Products 79(10):2731-2739. PMCID: PMC5217177
Wang X, Reynolds AR, Elshahawi SI, Shaaban KA, Ponomareva LV, Saunders MA, Elgumati IS, Zhang Y, Copley GC, Hower JC, Sunkara M, Morris AJ, Kharel MK, Van Lanen SG, Prendergast MA, Thorson JS (2015). Terfestatins B and C, new p-terphenyl glycosides produced by Streptomyces sp. RM-5-8. Organic Letters 17(11):2796-2799. PMCID: PMC4472964
Wang X, Elshahawi SI, Shaaban KA, Fang L, Ponomareva LV, Zhang Y, Copley GC, Hower JC, Zhan CG, Kharel MK, Thorson JS (2014). Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15. Organic Letters 16(2):456-459. PMCID: PMC3964319
Wang X, Shaaban KA, Elshahawi SI, Ponomareva LV, Sunkara M, Zhang Y, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS (2013). Frenolicins C-G, pyranonaphthoquinones from Streptomyces sp. RM-4-15. Journal of Natural Products 76(8):1441-1447. PMCID: PMC3862173
We welcome inquiries from UK investigators interested in exploring new applications of novel natural products, small molecules, and/or approved drugs. For more information or to request services/resources, please contact us.
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