Under the directorship of Professor Khaled Shaaban, CPRI has developed the CPRI Natural Products Repository as UK-exclusive enabling resource. This repository is a growing collection of >420 pure natural products (>50% of which are unique to our collection) produced by microbes isolated from subterranean environments in Appalachian Kentucky (through strategic collaborations with KY-based underground mining and drilling operations).
This effort has expanded to include strategic international collaborations to enable access to new ecological niches and natural products (Dr. Chirlei Glienke, Federal University of Paraná; Dr. Imran Sajid, University of the Punjab, Pakistan; Dr. Changsheng Zhang, South China Sea Institute of Oceanology, China). As part of our natural products emphasis, CPRI also houses >1100 distinct actinomycete strains and corresponding fractionated extracts in screenable format. CPRI has also identified overproduction sources for a number of specialty natural products and continues to build a collection of UK-exclusive synthetics to further facilitate translational research activities.
In addition to the UK-exclusive compound collections emphasized above, CPRI continues to maintain and build a collection of commercially-sourced compound collections to support screening projects (including those focused on drug repurposing/repositioning). All CPRI compound collections listed below are available in a standard screenable format via the Translational Core and, for select projects, compounds can also be provided on larger scale for medicinal chemistry, mechanistic studies, in vivo assessment and/or development activities through the Synthesis Core.