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Pharmacy Practice & Science Dept.
Graduate Studies
Location
Lee T. Todd, Jr. Bldg, Room 231
Phone
859-323-8751
Email
david.feola@uky.edu

Dr. Feola received his Doctor of Pharmacy and Philosophy degrees from the University of Kentucky College of Pharmacy. He also completed residencies in pharmacy practice and infectious diseases pharmacotherapy at the UK Chandler Medical Center (R258). His primary research focus area is immunology and infectious disease pharmacotherapy, with specific projects investigating immunomodulatory and immunotoxic properties of drug exposure in animals and humans. Dr. Feola has built a translational research program through which he utilizes animal models and molecular and cellular investigations to generate investigator-initiated clinical trials. He leads a research program focused on mechanistic and translational investigations to define the role of alternatively activated macrophages in the pathophysiology of pulmonary fibrosis. This is accomplished through the use of a mouse model of Pseudomonas aeruginosa infection and through clinical studies in patients with cystic fibrosis. The goal of this research is to improve the understanding of chronic inflammatory lung diseases and to help identify potential therapeutic targets to slow the progression of chronic inflammation and tissue remodeling.


Alternatively activated macrophages are involved in the promotion of Th2-type immune responses, debris scavenging, tissue remodeling, and fibrosis. These cells have also been shown to inhibit both Th1-type responses and the function of classically activated macrophages responsible for the initiation and propagation of inflammation. In a series of randomized, clinical trials, azithromycin (AZM) has been shown to favorably impact morbidity and mortality in patients with cystic fibrosis infected with P. aeruginosa. His group demonstrated that AZM will polarize macrophages to an alternative-like phenotype both in vitro and in a mouse model of pulmonary infection. He additionally collaborates across UK and beyond to study the regulatory functions of macrophages in acute myocardial infarction, spinal cord injury, and other pathologies.


Dr. Feola also teaches infectious disease pharmacotherapy in the Integrated Drugs and Diseases course sequence for the Doctor of Pharmacy Program supports clinical services at the UK Chandler Medical Center and serves as the Director of Graduate Studies for the College of Pharmacy. His interest in exploring and implementing cutting-edge training approaches in graduate education has expanded his impact to include the evolution of training in the pharmaceutical sciences.

PUBLICATIONS

Faculty Expertise

  • COVID-19
  • Immunology
  • Innovative Teaching
  • Viral and Bacterial Infectious Disease

Positions

Director of Graduate Studies

Education

Doctor of Philosophy, Clinical Pharmaceutical Sciences University of Kentucky College of Pharmacy

Specialty Residency in Infectious Disease Pharmacy University of Kentucky Hospital

Residency in Pharmacy Practice University of Kentucky Hospital

PharmD Univ Of Kentucky

BS University of Kentucky

We wish to remember and honor those who inhabited this Commonwealth before the arrival of the Europeans. Briefly occupying these lands were the Osage, Wyndott tribe, and Miami peoples. The Adena and Hopewell peoples, who are recognized by the naming of the time period in which they resided here, were here more permanently. Some of their mounds remain in the Lexington area, including at UK’s Adena Park.

In more recent years, the Cherokee occupied southeast Kentucky, the Yuchi southwest Kentucky, the Chickasaw extreme western Kentucky and the Shawnee central Kentucky including what is now the city of Lexington. The Shawnee left when colonization pushed through the Appalachian Mountains. Lower Shawnee Town ceremonial grounds are still visible in Greenup County.

We honor the first inhabitants who were here, respect their culture, and acknowledge the presence of their descendants who are here today in all walks of life including fellow pharmacists and healthcare professionals.