The Bio Core commonly engages in assay development/validation/implementation, virtual and wet bench screening, hit identification, and hit/lead candidate validation studies. Virtual and wet bench screening activities in the core employ both commercially available libraries and our exclusive UK-based collections (see Compound Collections). The CTCB Bio Core works closely with the CTCB Chem Core for medchem-guided probe/lead prioritization. The Bio Core is directed by Professor Steven Van Lanen and co-directed by Professor Chang-Guo Zhan.
The Bio Core welcomes inquiries from UK investigators with an interest in the application of assay development/validation, virtual or bioactivity-guided screening, and/or chemical biology approaches to facilitate on-going or emerging research projects. For more information and to request services, please contact us.
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This work was supported by the University of Kentucky COBRE for Translational Chemical Biology (CTCB, NIH P20 GM130456) and the University of Kentucky Center for Clinical and Translational Science (CCTS, NIH UL1 TR001998).
