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Sylvie Garneau-Tsodikova headshot
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Pharmaceutical Sciences Dept.
Location
Lee T. Todd, Jr. Bldg, Room 423
Phone
859-218-1686
Email
sgt229@uky.edu

Sylvie Garneau-Tsodikova graduated in 1995 at the top of her class in chemistry and obtained her M.Sc. in 1997 from Université Laval (Québec, Canada) where she received numerous awards (Chemical Institute of Canada, National Sciences and Research Council of Canada "NSERC," Fonds québécois de la recherche sur la nature et les technologies, Price Foundation, and Lucien Piché fellowship).

She then joined the Ph.D. program in chemistry at the University of Alberta (Edmonton, Canada). During her graduate studies as an NSERC, Alberta Heritage Foundation for Medical Research and Izaak Walton Killam scholar, under the supervision of Professor John C. Vederas, she received rigorous training in chemistry and biochemistry. Her work in the Vederas' group focused on the discovery and synthesis of new antimicrobial agents acting on bacterial cell walls.

From Alberta, Dr. Garneau-Tsodikova moved to Harvard Medical School where she worked as a postdoctoral fellow in Professor Christopher T. Walsh's laboratory. Through her studies on the formation and modification (halogenation) of mono- and dipyrroles in a variety of secondary metabolites, she obtained extensive training in mechanistic enzymology and strengthened her skills in biochemistry.

From 2006-2013 she joined the University of Michigan as the John G. Searle Assistant Professor of Medicinal Chemistry in the College of Pharmacy and Research Assistant Professor in the Life Sciences Institute.

In April 2013 she joined the University of Kentucky as an Associate Professor of Pharmaceutical Sciences in the College of Pharmacy.

In 2018 she was promoted to Full Professor and Assistant Dean for Research in the College of Pharmacy.

Using a multidisciplinary approach involving disciplines such as molecular biology, microbiology, biochemistry, as well as organic and medicinal chemistry, she is addressing several issues in synthetic biology and chemistry. Her research program has two main focuses: (i) the understanding of enzyme mechanisms involved in the biosynthesis of nonribosomal/polyketide antibiotics and anticancer agents as well as the development of new tools to generate and engineer novel nonribosomal peptides through combinatorial biosynthesis, and (ii) the understanding and development of new molecules to combat bacterial resistance with a special focus on tuberculosis, fungal infections, and oral pathogens.

PUBLICATIONS

Expertise

  • Infectious Diseases
  • Bacterial and Fungal Resistance
  • Natural Products
  • Enzyme Engineering

Positions

  • Professor of Pharmaceutical Sciences
  • Patrick P. DeLuca Pharmaceutical Technology Professor
  • Assistant Vice President for Research

We wish to remember and honor those who inhabited this Commonwealth before the arrival of the Europeans. Briefly occupying these lands were the Osage, Wyndott tribe, and Miami peoples. The Adena and Hopewell peoples, who are recognized by the naming of the time period in which they resided here, were here more permanently. Some of their mounds remain in the Lexington area, including at UK’s Adena Park.

In more recent years, the Cherokee occupied southeast Kentucky, the Yuchi southwest Kentucky, the Chickasaw extreme western Kentucky and the Shawnee central Kentucky including what is now the city of Lexington. The Shawnee left when colonization pushed through the Appalachian Mountains. Lower Shawnee Town ceremonial grounds are still visible in Greenup County.

We honor the first inhabitants who were here, respect their culture, and acknowledge the presence of their descendants who are here today in all walks of life including fellow pharmacists and healthcare professionals.