Caroline Geisler, PhD

Assistant Professor

Dr. Caroline Geisler is a metabolic neuroscientist with expertise in the neuroendocrine control of energy balance and obesity-associated metabolic dysregulation.

Dr. Geisler acquired a strong foundation for investigating systemic metabolic function through preclinical mouse models of obesity during her graduate training under Dr. Ben Renquist at the University of Arizona. Her PhD in Animal Sciences, awarded in 2019, focused on the hepatic metabolic adaptations to lipid accumulation and how this dysregulated systemic insulin and glucose homeostasis. She then joined the behavioral neuroscience lab of Dr. Matt Hayes at the University of Pennsylvania, where, as a postdoctoral fellow, she studied how gut-derived satiation hormones signal in various energy-regulating brain centers to control appetite, body weight, and food-directed motivated behaviors.

Dr. Geisler's research program aims to understand how the brain and body communicate and integrate nutrient-state-dependent signals, specifically the role of glial cells in central glucose sensing and regulation of systemic metabolism. Understanding the mechanisms behind dysregulated central control of energy homeostasis is critical to mitigating the damage of many disorders with underlying metabolic derangements linked to obesity, including type 2 diabetes, CVD, cancers, and neurodegenerative diseases.

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