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Pharmaceutical Sciences Dept.
Executive Team
Lee T. Todd, Jr. Bldg, Ste 216

Dr. Guy obtained his BA in chemistry from Reed College in Portland, OR in 1990. After college, he worked as a process development chemist in the Process Translation Unit at IBM-Almaden in San Jose, CA. In 1996, he received his PhD in Organic Chemistry based on the total synthesis of taxol from the Scripps Research Institute (TSRI) La Jolla, CA. He also carried out additional training in Physiology at the Woods Hole Research Institute in Woods Hole, MA in 1995. From 1996 to 1998, he was a Helen Hay Whitney Postdoctoral Fellow in Cellular Biology focusing on the relationship between hedgehog signaling and sterol homeostasis with Drs. Brown and Goldstein at University of Texas Southwestern Medical Center, Dallas, TX. In 1998 he joined UCSF as an Assistant Professor with joint appointments in Pharmaceutical Chemistry and Cellular and Molecular Pharmacology. In 2002 he founded the Center for Chemical Diversity at UCSF, which provided access to high throughput chemistry to the campus. In 2003 he founded the Bay Area Screening Center, a joint endeavor between UCSF and the Gallo Institute that provided high throughput screening. These were subsequently merged into the Small Molecule Discovery Center. In 2005, he was promoted directly to Full Professor. In 2005 he was recruited to St Jude Children’s Research Hospital, Memphis, TN, to found and chair the new department of Chemical Biology and Therapeutics where he was the Robert J. Ulrich Chair in Chemical Biology and Therapeutics. His research is focused on the discovery and development of novel small molecules that target the pathophysiology of orphan diseases, particularly pediatric oncology and protozoal infectious diseases. Most of his group’s work falls into the areas of chemical validation of novel targets, lead discovery and optimization of novel chemical matter for validated disease targets, and use of non-targeted whole-cell strategies for lead discovery and optimization.



Faculty Expertise

  • Blood Cancers
  • Breast Cancer
  • Brain/Intracranial Cancer
  • Prostate Cancer
  • Diversity, Equity, and Inclusion 
  • Health Disparities 
  • Drug Discovery & Development
  • Parasitic and Viral Diseases

We wish to remember and honor those who inhabited this Commonwealth before the arrival of the Europeans. Briefly occupying these lands were the Osage, Wyndott tribe, and Miami peoples. The Adena and Hopewell peoples, who are recognized by the naming of the time period in which they resided here, were here more permanently. Some of their mounds remain in the Lexington area, including at UK’s Adena Park.

In more recent years, the Cherokee occupied southeast Kentucky, the Yuchi southwest Kentucky, the Chickasaw extreme western Kentucky and the Shawnee central Kentucky including what is now the city of Lexington. The Shawnee left when colonization pushed through the Appalachian Mountains. Lower Shawnee Town ceremonial grounds are still visible in Greenup County.

We honor the first inhabitants who were here, respect their culture, and acknowledge the presence of their descendants who are here today in all walks of life including fellow pharmacists and healthcare professionals.