BS pharmacy, Wisconsin; PhD pharmacology, Minnesota; Post-doc, Concordia University, Montreal; UK Alumni Association Great Teacher; NIH Research Career Development Awardee; Provost’s Distinguished Service Professor; ~ 145 publications; 22 book, encyclopedia or online reference database chapters; four patents.
Dr. Yokel has had a long-term, continuing, interest in aluminum, including its adverse effects, pharmacokinetics, chelation, and occurrence in human sources.
His current research focuses on the biological effects of nanomaterials, specifically the effects of nanoscale cerium dioxide that he is pursuing with a diverse team of collaborators. Continuing his career-long interest in drug/chemical interaction with the nervous system, he is interested in the ability of nanomaterials to enter the brain and their effects on the nervous system.
Yokel Robert A, Hussain S, Garantziotis S, Demokritou P, Castranova V, Cassee F R. (2014). The Yin: An adverse health perspective of nanoceria: uptake, distribution, accumulation, and mechanisms of its toxicity.Environmental science. Nano, 1(5), 406-428.
Willhite C C, Karyakina N A, Yokel Robert A, Yenugadhati N, Wisniewski T M, Arnold I M, Momoli F, Krewski D. (2014). Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts.Critical reviews in toxicology, 44 Suppl 4, 1-80.
Yokel Robert A, Unrine Jason M, Wu Peng, Wang Binghui , Grulke Eric A. (2014). Nanoceria biodistribution and retention in the rat are not
greatly influenced by dosing schedule, dose, or particle
shape.Environmental Sciences: Nano/Royal Society of Chemistry, 1, 549-560.
Graham Uschi M, Tseng Michael T, Jasinski J B, Yokel Robert A, Unrine Jason M, Davis B H, Dozier A K, Hardas Sarita S, Sultana Rukhsana, Grulke Eric A, Butterfield David. (2014). In vivo processing of ceria nanoparticles inside liver: Impact on free radical scavenging activity and oxidative stress.ChemPlusChem, 79(8), 1083-1088.
Sjögren Bendt, Iregren Anders, Montelius Johan, Yokel Robert A. (2014). Aluminum.Academic Press, II(4th), Chapter 26, pages 549-564.
Hardas S S, Sultana Rukhsana, Warrier G, Dan M, Wu P, Grulke Eric A, Tseng M T, Unrine Jason M, Graham U M, Yokel Robert A, Butterfield David. (2014). Rat hippocampal responses up to 90 days after a single nanoceria dose extends a hierarchical oxidative stress model for nanoparticle toxicity.Nanotoxicology, 8, 155-166.