Dr. Patrick McNamara
Dr. Patrick McNamara

Professor

Patrick J. McNamara received his Ph.D. in Pharmaceutical Sciences from the State University of New York at Buffalo in 1979. He joined the faculty at the University of Kentucky in 1980 and has advanced through the academic ranks. Prior to his appointment as Senior Associate Dean for the College of Pharmacy, he served as Director (Division of Pharmaceutics and Pharmaceutical Analysis; Pharmacology and Experimental Therapeutics; and Pharmaceutical Sciences), Chair of the Department of Pharmaceutical Sciences, Associate Dean for Research and Director of Graduate Studies as well as Interim Dean of the College of Pharmacy. Dr. McNamara has a joint appointment in the Graduate Center for Toxicology and is a member of the Markey Cancer Center. He is a Fellow in American Association of Pharmaceutical Sciences and the American Association for the Advancement of Science. He serves on the Editorial Advisory Board for the Journal of Pharmaceutical Sciences and serves as a reviewer for numerous journals. Dr. McNamara has served as a consultant to a number of pharmaceutical companies. Dr. McNamara's scholarly interests are in the areas of pharmacokinetics and pharmacodynamics, with a particular emphasis on drug transport into milk and the ontogeny of clearance pathways. Dr. McNamara's most recent work has focused on the mechanisms of drug transfer into milk, including transporter gene expression at the blood mammary epithelial barrier. Ongoing research also examines influence of transporters expressed at the blood brain barrier on the penetration of drugs into the CNS. Other projects include modeling the pharmacodynamic of bacterial resistance mechanisms (i.e., up-regulation of efflux transporters and mutations of QRDRs) upon exposure to fluroquinolones. Dr. McNamara's research program utilizes contemporary technology, including cell culture, molecular biology, whole-animal and clinical studies, microdialysis, high-performance liquid chromatography, computer model fitting and simulations.

Recent Publications

  • Romanelli Frank, Cain Jeffrey John, McNamara Patrick J. (2014). Should TED Talks Be Teaching Us Something?. Am J Pharmaceut Ed,
  • Procter Levi David, Meier Cindy f, Hamilton Charles, Overall P, Santapuram P, Davenport Daniel L., McNamara Patrick J., Woodward Jerold G., Bernard Andrew C. (2013). y+ cationic amino acid transport of arginine in packed red blood cells. J Surg Res, Jan;179(1), e183-7.
  • Wang L, McNamara Patrick J. (2012). Stereoselective interaction of pantoprazole with ABCG2. I. Drug accumulation in rat milk. Drug metabolism and disposition: the biological fate of chemicals, 40(5), 1018-23.
  • Wang L, Leggas Markos, Empey P E, McNamara Patrick J. (2012). Stereoselective interaction of pantoprazole with ABCG2. II. In vitro flux analysis. Drug metabolism and disposition: the biological fate of chemicals, 40(5), 1024-31.
  • Kuo K L, Zhu Haining, McNamara Patrick J., Leggas Marko. (2012). Localization and functional characterization of the rat Oatp4c1 transporter in an in vitro cell system and rat tissues. PloS one, 7(6), e39641.
  • Blumenschein Karen M., McNamara Patrick J., Brogden N K. (2011). Integration of Transdermal Formulation Development and Clinical Trial Design in the PharmD Curriculum. American Association of Colleges of Pharmacy Annual Meeting,, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142979/
  • McNamara Patrick J., Leggas Marko. (2009). Drug Distribution. Elsevier, 113-129.
  • Empey P, Leggas Markos, Wang L, McNamara Patrick J. (2009). Limitations in the analysis of transcellular flux from a monolayer system. American Association of Pharmaceutical Scientists,
  • McNamara Patrick J., Goswami M, Leggas Markos, Wang L. (2009). Pantoprazole isomer transport by human and rat ABCG2 expressed in MDCKII cells. American Association of Pharmaceutical Scientists, http://www.aapsj.org/abstracts/AM_2009/AAPS2009-003870.PDF
  • Wang L, Leggas Markos, Goswami M, Empey P E, McNamara Patrick J. (2008). N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide (GF120918) as a chemical ATP-binding cassette transporter family G member 2 (Abcg2) knockout model to study nitrofurantoin transfer into milk. Drug metabolism and disposition: the biological fate of chemicals, 36(12), 2591-6.