Dr. Patrick Marsac
Dr. Patrick Marsac

Associate Professor

Having received a B.S. in Chemical Engineering (2001) and a M.S. in Pharmaceutical Engineering (2002) from the University of Michigan, Patrick Marsac then graduated from Purdue University with a Ph.D. in Industrial and Physical Pharmacy (2007). He worked at Merck and Co. for 8 years and then joined UKY College of Pharmacy in September of 2015.

Interests

  • Advanced analytics of materials and associated implications in drug discovery and development.
  • Application of engineering principles to biological systems.
  • Thermodynamics and kinetics of phase changes of solid state pharmaceutical products.

Recent Publications

  • Nie H, Xu W, Taylor L S, Marsac Patrick Jules, Byrn S R. (2016). Crystalline solid dispersion-a strategy to slowdown salt disproportionation in solid state formulations during storage and wet granulation. International journal of pharmaceutics,
  • Nie H, Su Y, Zhang M, Song Y, Leone A, Taylor L S, Marsac Patrick Jules, Li T, Byrn S R. (2016). Solid-State Spectroscopic Investigation of Molecular Interactions between Clofazimine and Hypromellose Phthalate in Amorphous Solid Dispersions. Molecular pharmaceutics, 13(11), 3964-3975.
  • Nie H, Xu W, Ren J, Taylor L S, Marsac Patrick Jules, John C T, Byrn S R. (2016). Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations. Molecular pharmaceutics, 13(10), 3541-3552.
  • Mitra A, Li L, Marsac Patrick Jules, Marks B, Liu Z, Brown C. (2016). Impact of polymer type on bioperformance and physical stability of hot melt extruded formulations of a poorly water soluble drug. International journal of pharmaceutics, 505(1-2), 107-14.
  • Nie H, Liu Z, Marks B C, Taylor L S, Byrn S R, Marsac Patrick Jules. (2016). Analytical approaches to investigate salt disproportionation in tablet matrices by Raman spectroscopy and Raman mapping. Journal of pharmaceutical and biomedical analysis, 118, 328-37.
  • Yildiz H M, McKelvey C A, Marsac Patrick Jules, Carrier R L. (2015). Size selectivity of intestinal mucus to diffusing particulates is dependent on surface chemistry and exposure to lipids. Journal of drug targeting, 23(7-8), 768-74.
  • Boersen Nathan, Brown Chad, DiNunzio James, Johnson David, Marsac Patrick Jules, McKelvey Craig, Meyer Robert. (2014). Hot-Melt Extrusion: The Process-Product-Performance Interplay. Springer Scientific,
  • Brown Chad, DiNunzio James, Eglesia Mike, Forster Seth, Lamm Matthew, Lowinger Michael, Marsac Patrick Jules, McKelvey Craig, Meyer Robert, Schenck Luke, Terife Graciela, Troup Gregory, Smith-Goettler Brandy, Starbuck Cindy. (2014). HME for Solid Dispersions: Composition and Design Considerations. Springer Scientific,
  • Brown Chad, DiNunzio James, Eglesia Mike, Forster Seth, Lamm Matthew, Lowinger Michael, Marsac Patrick Jules, McKelvey Craig, Meyer Robert, Schenck Luke, Terife Graciela, Troup Gregory, Smith-Goettler Brandy, Starbuck Cindy. (2014). HME for Solid Dispersions: Scale-Up and Late-Stage Development. Springer Scientific,
  • Ilevbare Grace, Marsac Patrick Jules, Mitra Amitava. (2014). Performance and Characterization of Solid Dispersions: An Overview. Springer Scientific,