Dr. Markos Leggas
Dr. Markos Leggas

Associate Professor

Dr. Leggas joined the University of Kentucky College of Pharmacy in 2004 and his research efforts have focused on preclinical and clinical pharmacology and translational projects to develop drugs or repurpose clinically approved ones. Currently, Dr. Leggas' research is supported by funding from the NIH and the Department of Defense. His laboratory emphasizes the use of molecular and cellular biology along with classical pharmacology tools like pharmacokinetic and pharmacodynamic experiments, modeling and simulation to rapidly and rationally accelerate drug development. A major research focus of the Leggas laboratory is placed on discovering and developing drug that inhibit oncogenic transcription factors. Dr. Leggas is also serving as the leader for the Translational studies core in the Center for Pharmaceutical Research and Innovation, which facilitates preclinical and clinical drug development efforts across Kentucky.


  • Clinical Pharmacology and Experimental Therapeutics and Anticancer Drugs
  • Modeling and Simulation
  • Pharmacokinetics and pharmacodynamics
  • Targeting transcription factors
  • Gastrointestinal Physiology, Muscle Physiology, Bone Physiology, Pharmacokinetics/Pharmacodynamics

Recent Publications