Dr. Kim’s research lies at the interface between chemistry and biology. Specifically, the Kim lab focuses on the development and biological/pharmacological characterization of small molecule inhibitors targeting the proteasome-ubiquitin pathway.
Current research focuses on the development of immunoproteasome inhibitors that can be used as lead compounds in drug development process as well as molecule probes to investigate the function of the immunoproteasome..
Cornish Carmony K, Sharma L K, Park J E, Lee Wooin, Kim Kyung Bo. (2014). Elucidating the Catalytic Subunit Composition of Distinct Proteasome Subtypes: A Crosslinking Approach Employing Bifunctional Activity-Based Probes.Chembiochem : a European journal of chemical biology,
Kasam V, Lee N R, Kim Kyung Bo, Zhan C.-G. (2014). Selective immunoproteasome inhibitors with non-peptide scaffolds identified from structure-based virtual screening.Bioorganic & Medicinal Chemistry Letters, 24(15), 3614-7.
de Bruin G, Huber E M, Xin B T, van Rooden E J, Al-Ayed K, Kim Kyung Bo, Kisselev A F, Driessen C, van der Stelt M, van der Marel G A, Groll M, Overkleeft H S. (2014). Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes.Journal of medicinal chemistry, 57(14), 6197-209.
Park J E, Wu Yadi, Carmony K C, Miller Z, Sharma L K, Lee D M, Kim Doo Young, Lee Wooin, Kim Kyung Bo. (2014). A FRET-based approach for identification of proteasome catalytic subunit composition.Molecular bioSystems, 10(2), 196-200.
Ghosh P, Kim Kyung Bo, Stinchcomb Audra L. (2014). Optimization of naltrexone diclofenac codrugs for sustained drug delivery across microneedle-treated skin.Pharmaceutical research, 31(1), 148-59.
Miller Z, Lee Wooin, Kim Kyung Bo. (2014). The immunoproteasome as a therapeutic target for hematological malignancies.Current cancer drug targets, 14(6), 537-48.
Park J. E., Ao L., Miller Z., Wu Y., Jang E. R., Lee Eun Y., Kim Kyung Bo, Lee Wooi. (2013). PSMB9 Codon 60 Polymorphisms Have No Impact on the Activity of the Immunoproteasome Catalytic Subunit 1i Expressed in Multiple Types of Solid Cancer.PLOS ONE , 8(9:), e73732.dx.plos.org/10.1371/journal.pone.0073732
Carmony K C, Kim Kyung Bo. (2013). Activity-based imaging probes of the proteasome.Cell biochemistry and biophysics, 67(1), 91-101.
Kim Kyung Bo, Crews C M. (2013). From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes.Natural product reports, 30(5), 600-4.
Miller Z, Ao L, Kim Kyung Bo, Lee Wooi. (2013). Inhibitors of the immunoproteasome: current status and future directions.Current pharmaceutical design, 19(22), 4140-51.