Dr. Munson's research interests lie in the area of using solid-state NMR spectroscopy, powder X-ray diffraction, and other techniques to characterize solid pharmaceuticals. Differences in the crystalline state of a drug may significantly change its physical and thermodynamic properties. For many drugs, multiple crystalline polymorphs exist whose crystal structures are not known. Solid-state 13C magic-angle spinning (MAS) NMR spectroscopy is a powerful technique for studying polymorphic systems. It can be used to determine the degree of crystallinity, to identify the number of crystallographically inequivalent sites in the unit cell, to study the dynamics of molecules via relaxation measurements, and to understand the molecular structure based on the chemical shift of the individual resonances.
Specific research areas that are being pursued in his group include the investigation of the structure and reactivity of pharmaceutical agents in polymer matrices; correlation of solid-state NMR chemical shifts with molecular structure; investigation of the transformations between crystalline and amorphous forms of pharmaceutical solids; effect of processing upon drug structure and stability; investigation of peptide and protein stability in formulations; and the effects of freeze drying upon drug stability.
Dr. Munson's research interests lie in the area of using solid-state NMR spectroscopy, powder X-ray diffraction, and other techniques to characterize solid pharmaceuticals.
Mensink M A, Nethercott M J, Hinrichs W L, van der Voort Maarschalk K, Frijlink H W, Munson Eric Jon, Pikal M J. (2016). Influence of Miscibility of Protein-Sugar Lyophilizates on Their Storage Stability.The AAPS journal,
Haware R V, Dave V S, Kakarala B, Delaney S, Staton S, Munson Eric Jon, Gupta M R, Stagner W C. (2016). Vegetable-derived magnesium stearate functionality evaluation by DM(3) approach.Eur J Pharm Sci, 89, 115-124.
Yuan X, Xiang T X, Anderson Bradley D, Munson Eric Jon. (2015). Hydrogen Bonding Interactions in Amorphous Indomethacin and Its Amorphous Solid Dispersions with Poly(vinylpyrrolidone) and Poly(vinylpyrrolidone-co-vinyl acetate) Studied Using (13)C Solid-State NMR.Molecular pharmaceutics, 12(12), 4518-28.
Calahan J L, Azali S C, Munson Eric Jon, Nagapudi K. (2015). Investigation of Phase Mixing in Amorphous Solid Dispersions of AMG 517 in HPMC-AS Using DSC, Solid-State NMR, and Solution Calorimetry.Molecular pharmaceutics, 12(11), 4115-23.
Yuan X, Sperger D, Munson Eric Jon. (2014). Investigating miscibility and molecular mobility of nifedipine-PVP amorphous solid dispersions using solid-state NMR spectroscopy.Molecular pharmaceutics, 11(1), 329-37.
Pyszczynski S J, Munson Eric Jon. (2013). Generation and characterization of a new solid form of trehalose.Molecular pharmaceutics, 10(9), 3323-32.
Calahan J L, Zanon R L, Alvarez-Nunez F, Munson Eric Jon. (2013). Isothermal microcalorimetry to investigate the phase separation for amorphous solid dispersions of AMG 517 with HPMC-AS.Molecular pharmaceutics, 10(5), 1949-57.
Dempah K E, Barich D H, Kaushal A M, Zong Z, Desai S D, Suryanarayanan R, Kirsch L, Munson Eric Jon. (2013). Investigating gabapentin polymorphism using solid-state NMR spectroscopy.AAPS PharmSciTech, 14(1), 19-28.
Wang H, Sheelan C, Block H, Moreton Richard, Wendt R, Apte S P, Munson Eric Jon. (2013). Fixed-oil excipient monographs development of USP fixed-oil reference standards.Pharm Tech, 37, 102-108.
Gorman E M, Samas B, Munson Eric Jon. (2012). Understanding the dehydration of levofloxacin hemihydrate.Journal of pharmaceutical sciences, 101(9), 3319-30.